Molecular data
| Molecular formula | C62H98N16O22 |
|---|---|
| Molecular weight | 1419.53 Da |
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
| Sequence length | 15 residues |
| CAS / identifier | 137525-51-0 |
| Physical form | Lyophilized powder |
| Available sizes | 10mg, 20mg |
How it works
VEGF & Angiogenic Signalling
In preclinical models, raised vascular endothelial growth factor (VEGF) expression has been measured following BPC-157 exposure, with vessel formation and perfusion recorded in the same models.
- Vessel formation measured in animal models (angiogenesis)
- Raised VEGF receptor expression reported
- Modulates nitric oxide signaling (NO system)
GHR Upregulation
Growth hormone receptor expression in cultured tendon fibroblasts has been measured at approximately 7× baseline within 3 days of exposure.
- 7× growth hormone receptor upregulation
- Tendon fibroblast viability measured in culture
- Collagen synthesis signalling examined
Cytoprotective Signalling
Cytoprotective endpoints have been examined across several organ systems in animal studies, most often in gastrointestinal and musculoskeletal tissue.
- Gastric mucosal integrity endpoints
- Faster wound closure recorded in animal models
- Neuroprotective endpoints observed in rodent models
What the research shows
Tendon & Ligament
Achilles tendon, MCL and rotator cuff models in rats, with collagen fibre organisation among the measured endpoints.
Gastrointestinal Models
Cytoprotective endpoints examined in NSAID-induced injury, alcohol lesion and colitis models.
Brain & Nervous System
Neuroprotective endpoints examined in traumatic brain injury and peripheral nerve models, including functional markers.
Vascular Models
Studied for angiogenesis after surgical transection in animal models, via NO system modulation.
Specification
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
|---|---|
| Molecular Weight | 1419.53 Da |
| Molecular Formula | C₆₂H₉₈N₁₆O₂₂ |
| Form | Lyophilized powder (5mg) |
| Purity | ≥99% (HPLC verified) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Storage | -20°C for long-term stability |
| Solubility | Water-soluble |
| COA | Included with every order |
Frequently asked questions
What is BPC-157 and where does it come from?
BPC-157 (Body Protection Compound-157) is a synthetic 15-amino acid peptide derived from a larger protein found in human gastric juice. It was first characterised at the University of Zagreb, Croatia, and has been studied extensively in animal models across cytoprotective and tissue-remodelling endpoints.
Is BPC-157 FDA approved?
No. BPC-157 is not approved by the FDA or any regulatory agency for human use. It is classified as an unapproved drug. The FDA has issued warnings about BPC-157 being found in compounded products and dietary supplements. Only one Phase I clinical trial has been registered, and no Phase 2 or 3 trials have been completed.
What does the research show about BPC-157?
Preclinical research (animal studies) has reported BPC-157 in tendon, ligament, muscle and bone models; in gastrointestinal lesion and inflammation models; in neuroprotection models of brain injury; and in blood-vessel formation. All findings are from animal studies - no human clinical data exists.
How is BPC-157 used in research settings?
BPC-157 has been studied in rodent models and in cultured cell systems, with tissue-remodelling and gastrointestinal endpoints. Study design, concentrations and endpoints differ between experiments.
What are the safety concerns with BPC-157?
No lethal dose was reached in preclinical toxicology studies, and no significant adverse effects have been reported in published research. However, BPC-157 has never completed human clinical trials, so its safety profile in humans is unknown. It should only be used for in vitro laboratory research.
How should BPC-157 be stored?
Lyophilized (powder) form should be stored at -20°C for long-term stability, protected from light and moisture. BPC-157 is a stable peptide — published work reports resistance to hydrolysis, enzymatic degradation, and gastric acid.
For laboratory research use only. Not a drug, supplement, or medical product; not for human or animal use. All findings referenced are from published preclinical/laboratory research.