Peptide · Research Monograph · Decapeptide KISS1R/GPR54 agonist

Kisspeptin

Reproductive Hormone Studies

Kisspeptin-10 is a ten amino acid peptide. It is the active piece of a longer peptide called kisspeptin-54. It binds a receptor named KISS1R. Studies have measured what happens in the hypothalamus after it binds, and how that signal moves down the reproductive hormone axis. Its discovery changed how the field understood where that signal begins.

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For laboratory research use only - not for human or animal use

Available in the Eon catalog - Kisspeptin from $75.00

Molecular data

Molecular formulaC63H83N17O14
Molecular weight1302.5 Da
SequenceTyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Sequence length10 residues
CAS / identifier374675-21-5
Physical formWhite lyophilized powder
Available sizes10mg

How it works

GPR54 Agonist

KISS1R / GPR54 Activation

Kisspeptin-10 is the shortest active fragment of the KISS1 gene product and binds KISS1R (GPR54) on hypothalamic GnRH neurons — the most potent known endogenous trigger of GnRH neuron activity.

GnRH ↑

GnRH Pulse Generation

Receptor activation evokes pulsatile GnRH secretion into the hypophyseal portal circulation, with both the frequency and amplitude of GnRH pulses measured rather than output alone.

LH / FSH ↑

Gonadotropin Release

Downstream of GnRH, the pituitary releases luteinizing hormone (robust) and follicle-stimulating hormone (more modest), letting researchers probe upstream control of the gonadal axis.

What the research shows

Reproductive Neuroendocrinology

GnRH Axis Probing

Used to evoke discrete LH pulses, enabling characterization of GnRH pulsatility and pituitary responsiveness in controlled models.

Fertility Research

Gonadotropin Response

Studied as a stimulus of endogenous LH/FSH to distinguish hypothalamic from pituitary components of reproductive dysfunction.

Development

Pubertal Signaling

Investigated for the role of KISS1/GPR54 signaling in the onset and timing of puberty.

Specification

Also Known AsKP-10, Metastin 45-54, Kisspeptin-112-121
TypeDecapeptide — KISS1R/GPR54 agonist
CAS Number374675-21-5
Molecular FormulaC63H83N17O14
Molecular Weight1,302.5 g/mol
Amino Acid SequenceTyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Physical AppearanceWhite lyophilized powder
Purity≥99% (HPLC)
Content10 mg per vial

Frequently asked questions

What is Kisspeptin-10?

Kisspeptin-10 (KP-10) is a synthetic decapeptide corresponding to the C-terminal active fragment of the kisspeptin family encoded by the KISS1 gene. It is a high-affinity agonist of the KISS1R (GPR54) receptor.

How does it differ from Kisspeptin-54?

Kisspeptin-54 is the longer parent peptide; Kisspeptin-10 retains the C-terminal decapeptide that carries full receptor activity, with a shorter sequence and faster in-vivo clearance.

What is GPR54 / KISS1R?

It is the G-protein-coupled receptor for kisspeptins, expressed on GnRH neurons; its activation is essential for normal reproductive-axis function.

How is it stored?

Supplied as a lyophilized powder; store at -20°C, protected from light and moisture. Research use only.

For laboratory research use only. Not a drug, supplement, or medical product; not for human or animal use. All findings referenced are from published preclinical/laboratory research.