Peptide · Research Monograph · Naturally occurring nonapeptide neuropeptide (WAGGDASGE)

DSIP

Studied in sleep-architecture, stress-response, and endocrine research

Also known as Delta Sleep-Inducing Peptide

DSIP stands for delta sleep-inducing peptide. It is nine amino acids long and was first isolated in 1977 from blood drawn during deep sleep. Studies have measured brain wave patterns, sleep timing, and stress hormone response. After nearly fifty years of research, no one has identified which receptor it binds. The mechanism is still an open question.

Formula
C₃₅H₄₈N₁₀O₁₅
Mol. weight
848.8 Da
Length
9 residues
CAS
62568-57-4
View product & pricing → Lot records & COAs

For laboratory research use only - not for human or animal use

DSIP vial from the Eon Peptides research catalog
Fig. 1DSIP · 5mg / 10mg · catalog photograph
Available in the Eon catalog - DSIP from $30.00 View certificate of analysisILS Laboratories · 99.17% purity · Lot DSIP-101926-10

The molecule, in three dimensions

C35H48N10O15848.8
Drag to turn
Residues · hover to locate9 residues
Heavy atoms
60
Bonds
61
Composition
C35 N10 O15
Rings
1
Metal centre
None
Chain length
9 residues

Every heavy atom is placed from the sequence with ideal bond lengths and angles, so the connectivity is exact. The pose is idealised, an extended chain, and is not a measured conformation. Identity for the lot in stock is confirmed by LC-MS on its certificate.

Structure viewer →
Fig. 2Ball-and-stick model of DSIP: 60 heavy atoms and 61 bonds placed from the 9-residue sequence with ideal geometry. Hydrogens are not drawn.

Molecular data

Molecular formulaC₃₅H₄₈N₁₀O₁₅
Molecular weight848.8 Da
SequenceTrp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Sequence length9 residues
CAS / identifier62568-57-4
Physical formWhite lyophilized powder
Available sizes5mg, 10mg

The sequence

DSIP is published as a 9-residue sequence. It is set below in reading order, ten residues to a row, numbered from the N-terminus. Every position is a standard L-amino acid.

Fig. 3Primary sequence of DSIP as published in the catalogue specification, 9 residues, numbered from the N-terminus. A filled square marks a residue with no one-letter code.

One-letterWAGGDASGE

Residues
9
Published as
Three-letter code
Termini
Not stated in the specification

How it works

  1. Neuromodulator

    Neurotransmitter Modulation

    DSIP has been reported to influence serotonin (5-HT), glutamate, dopamine and melatonin signaling - pathways tied to sleep onset and circadian timing.

  2. Delta Sleep Research

    Sleep Architecture

    Early studies associate DSIP with greater slow-wave (delta) sleep, shorter sleep onset and higher sleep efficiency, distinct from sedative-hypnotic mechanisms.

  3. Neuroprotective

    Stress & Neuroprotection

    Investigated for adaptation of the stress (HPA) axis and for neuronal oxidative-stress endpoints in neurodegeneration and stroke models.

What the research shows

  1. Sleep Research

    Sleep Architecture

    Studied for effects on slow-wave sleep, sleep efficiency and onset latency in animal and human models.

  2. Stress & Endocrine

    Stress Adaptation

    Investigated for modulation of the HPA axis and stress-response regulation.

  3. Neuroscience

    Neuroprotection

    Explored for antioxidant/neuroprotective effects in models of neurodegeneration and ischemic injury.

Specification

Also Known AsDelta Sleep-Inducing Peptide, Sleep-Promoting Peptide
TypeNonapeptide neuropeptide
CAS Number62568-57-4
Molecular FormulaC₃₅H₄₈N₁₀O₁₅
Molecular Weight848.8 g/mol
Amino Acid SequenceTrp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Physical AppearanceWhite lyophilized powder
Purity≥99% (HPLC)
Content10 mg per vial
AppearanceWhite to off-white powder
Stability24 months from manufacture date when stored properly
StorageStore at -20°C, protected from light

How it's tested

Every lot of DSIP released to the catalog carries a third-party certificate of analysis. 4 documented lots are on file for this compound, with reported HPLC purity from 99.12% to 99.61% (mean 99.36%), issued by ILS Laboratories, Accurate Test Labs and Freedom Diagnostics. 2 of 4 certificates record identity as confirmed.

Documented lots
4
Reported purity
99.12% to 99.61%
Mean purity
99.36%
Issuing labs
ILS Laboratories, Accurate Test Labs, Freedom Diagnostics
100% 99% 98% 99.36% Lot DSIP12302025-J · 2025-12-31 · 99.55%Lot AJ4AUX · 2026-08-07 · 99.12%Lot DSIP-090226-10 · 2026-09-03 · 99.61%Lot DSIP-101926-10 · 2026-10-19 · 99.17% 2025-12-31 2026-10-19
Fig. 4Reported HPLC purity of all 4 documented lots, plotted on the date each certificate was issued, 2025-12-31 to 2026-10-19. One point is one certificate; the points are not joined because the archive records lots, not a continuous measurement. Vertical window 98.00% to 100%, dashed rule is the mean at 99.36%.

All certificates in the COA library →

Frequently asked questions

What is DSIP?

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated in the 1970s from the cerebral venous blood of rabbits in an induced sleep state, studied as an endogenous modulator of sleep and stress.

Is DSIP naturally occurring?

Yes. DSIP is an endogenous neuropeptide found in the brain, hypothalamus and other tissues, which is part of why it is of interest as a physiological sleep regulator.

What is it researched for?

Primarily sleep regulation, but also stress adaptation, neuroprotection, chronic-pain models and studies of opioid/alcohol withdrawal.

How is it stored?

Supplied as a lyophilized powder; store at -20°C, protected from light and moisture. Research use only.

Selected preclinical literature

8 published studies on DSIP, limited by rule to animal models and cell-based (in vitro) work indexed in PubMed. Human trials, case reports and literature overviews are excluded. Titles appear as published and each links to its PubMed record; the list was resolved against PubMed on 2026-10-12. A listing describes what a study examined, not a property of the material supplied.

  1. Rats model

    Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke

    Molecules (Basel, Switzerland), 2021. PubMed PMID 34500605 · doi:10.3390/molecules26175173

  2. Rats model and in vitro

    Effect of Delta Sleep-Inducing Peptide on Functional State of Hepatocytes in Rats During Restraint Stress

    Bulletin of experimental biology and medicine, 2016. PubMed PMID 26902351 · doi:10.1007/s10517-016-3186-8

  3. Rats model

    JmjC-domain-containing histone demethylases of the JMJD1B type as putative precursors of endogenous DSIP

    Peptides, 2011. PubMed PMID 21262293 · doi:10.1016/j.peptides.2011.01.006

  4. Rats and Mice model

    Effect of delta sleep-inducing peptide on macromolecule biosynthesis in brain tissue of stressed rodents

    Bulletin of experimental biology and medicine, 2006. PubMed PMID 17152359 · doi:10.1007/s10517-006-0187-z

  5. Rats model

    Delta-sleep-inducing peptide potentiates anticonvulsive activity of valproate against metaphit-provoked audiogenic seizure in rats

    Pharmacology, 2006. PubMed PMID 16645330 · doi:10.1159/000093001

  6. Rats model

    Antiepileptic activity of delta sleep-inducing peptide and its analogue in metaphit-provoked seizures in rats

    Seizure, 2005. PubMed PMID 15911358 · doi:10.1016/j.seizure.2005.02.001

  7. Rats model

    Delta sleep-inducing peptide and its tetrapeptide analogue alleviate severity of metaphit seizures

    Pharmacology, biochemistry, and behavior, 2004. PubMed PMID 14751449 · doi:10.1016/j.pbb.2003.10.014

  8. Rats model and in vitro

    Delta sleep-inducing peptide blocks excitatory effects of glutamate on rat brain neurons

    Bulletin of experimental biology and medicine, 2002. PubMed PMID 12459854 · doi:10.1023/a:1020679815690

Other entries in this volume that bear on DSIP, with the reason each one is listed.

For laboratory research use only. Not a drug, supplement, or medical product; not for human or animal use. All findings referenced are from published preclinical/laboratory research.