Molecular data
| Molecular formula | C37H51N9O10S |
|---|---|
| Molecular weight | 813.93 Da |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Sequence length | 7 residues |
| Physical form | Lyophilized Powder |
| Available sizes | 10mg |
How it works
BDNF Modulation
Brain-derived neurotrophic factor (BDNF) levels up to 1.4-fold baseline have been measured in specific brain regions, alongside neuronal survival and synaptic plasticity endpoints.
- BDNF expression up to 1.4× measured
- Neuronal survival and growth measured
- Synaptic plasticity measured
Serotonin & Dopamine Modulation
Research demonstrates Semax modulates serotonergic and dopaminergic systems, influencing mood regulation, attention, and cognitive processing in preclinical models.
- Modulates serotonin metabolism
- Influences dopaminergic signaling
- Affects noradrenergic pathways
Ischemic Models
In ischemic stroke models, infarct volume, inflammatory gene expression and neuronal survival under oxygen deprivation are the recorded endpoints.
- Infarct volume measured in stroke models
- Anti-inflammatory gene modulation
- Neuronal oxidative stress markers measured
What the research shows
Memory & Learning
Cognitive function, memory consolidation and attention measures are recorded in animal models. The Russian pharmaceutical formulation has been approved there as a nootropic since 2011.
Cerebral Ischemia Models
Infarct volume and neuronal survival are measured in cerebral ischemia models. The Russian pharmaceutical formulation is used clinically there; that use does not extend to this research material.
BDNF & Neurotrophin Signalling
Neurotrophin and receptor expression are measured, alongside neuronal plasticity endpoints.
Immune Modulation
Lower pro-inflammatory cytokines and altered oxidative stress-related gene expression are measured in hippocampal tissue.
Specification
| Strength | 10mg |
|---|---|
| Molecular Formula | C37H51N9O10S |
| Molecular Weight | 813.93 g/mol |
| Purity | >99% (HPLC) |
| Form | Lyophilized Powder |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Origin | Synthetic analog of ACTH(4-10) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Storage | -20°C for up to 24 months |
| Solubility | Water-soluble |
| COA | Included with every order |
| Appearance | White to off-white powder |
Frequently asked questions
What is Semax and where does it come from?
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide derived from the first four amino acids of adrenocorticotropic hormone (ACTH 4-10). It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s and has been approved in Russia as a prescription nootropic since 2011.
What has research shown about Semax?
Reported measures include BDNF levels up to 1.4-fold baseline, changes in serotonergic and dopaminergic systems, neuroprotective endpoints in ischemic stroke models, cognitive and memory measures in animal studies, and anti-inflammatory markers.
Is Semax FDA approved?
Semax is not approved by the FDA for any medical use in the United States. It is approved in Russia as a prescription medication for cognitive disorders and stroke recovery. In the US, it is available only as a research peptide for in vitro laboratory use.
How does Semax differ from N-Acetyl Semax?
N-Acetyl Semax (NASA) has an acetyl group added to the N-terminus, which raises stability and resistance to enzymatic degradation. Half-life is correspondingly longer than standard Semax.
How should Semax be stored?
Lyophilized Semax should be stored at -20°C for long-term stability (up to 24 months). Protect from heat and direct light.
For laboratory research use only. Not a drug, supplement, or medical product; not for human or animal use. All findings referenced are from published preclinical/laboratory research.