Memory & Learning
Cognitive function, memory consolidation and attention measures are recorded in animal models. The Russian pharmaceutical formulation has been approved there as a nootropic since 2011.
≥99% Purity
Semax
Cognitive Function Studies
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About this compound
Semax is a seven amino acid peptide developed at a Russian research institute. Part of its sequence comes from ACTH, a hormone, and the rest is a short tail that keeps enzymes from breaking it down. Research in rodent models has measured BDNF, a protein involved in neuron growth, along with dopamine and serotonin activity. Despite the ACTH origin, it shows no stress hormone activity in testing.
Synthetic heptapeptide analog of ACTH(4-10)
- Formula
- C37H51N9O10S
- Molecular weight
- 813.93 g/mol
- Form
- Lyophilized Powder
- Sequence length
- 7 residues
0.0×
BDNF (fold change)
Brain-derived neurotrophic factor
0
Amino Acids
ACTH(4-10) synthetic analog
0
Approved in Russia
Prescription nootropic since 2011
0
Research Areas
Memory & Learning Models · Cerebral Ischemia · BDNF Signalling & more
How It Works
How Semax works
The pathways Semax acts on — and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
BDNF Modulation
Neurotrophic
Brain-derived neurotrophic factor (BDNF) levels up to 1.4-fold baseline have been measured in specific brain regions, alongside neuronal survival and synaptic plasticity endpoints.
- BDNF expression up to 1.4× measured
- Neuronal survival and growth measured
- Synaptic plasticity measured
Serotonin & Dopamine Modulation
Neurotransmitter
Research demonstrates Semax modulates serotonergic and dopaminergic systems, influencing mood regulation, attention, and cognitive processing in preclinical models.
- Modulates serotonin metabolism
- Influences dopaminergic signaling
- Affects noradrenergic pathways
Ischemic Models
Neuroprotective
In ischemic stroke models, infarct volume, inflammatory gene expression and neuronal survival under oxygen deprivation are the recorded endpoints.
- Infarct volume measured in stroke models
- Anti-inflammatory gene modulation
- Neuronal oxidative stress markers measured
Uses & Applications
What Semax is researched for
The main areas Semax is being studied for — and the study-reported figures behind them.
Cerebral Ischemia Models
Infarct volume and neuronal survival are measured in cerebral ischemia models. The Russian pharmaceutical formulation is used clinically there; that use does not extend to this research material.
BDNF & Neurotrophin Signalling
Neurotrophin and receptor expression are measured, alongside neuronal plasticity endpoints.
Immune Modulation
Lower pro-inflammatory cytokines and altered oxidative stress-related gene expression are measured in hippocampal tissue.
Molecular Structure
The Semax molecule
An interactive 3D model rendered from the compound record — rotate and explore its structure.
C37H51N9O10S
Compound Information
Full specification
| Strength | 10mg |
| Molecular Formula | C37H51N9O10S |
| Molecular Weight | 813.93 g/mol |
| Purity | >99% (HPLC) |
| Form | Lyophilized Powder |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Origin | Synthetic analog of ACTH(4-10) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Storage | -20°C for up to 24 months |
| Solubility | Water-soluble |
| COA | Included with every order |
| Appearance | White to off-white powder |
FAQ
Common questions about Semax
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide derived from the first four amino acids of adrenocorticotropic hormone (ACTH 4-10). It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s and has been approved in Russia as a prescription nootropic since 2011.
Reported measures include BDNF levels up to 1.4-fold baseline, changes in serotonergic and dopaminergic systems, neuroprotective endpoints in ischemic stroke models, cognitive and memory measures in animal studies, and anti-inflammatory markers.
Semax is not approved by the FDA for any medical use in the United States. It is approved in Russia as a prescription medication for cognitive disorders and stroke recovery. In the US, it is available only as a research peptide for in vitro laboratory use.
N-Acetyl Semax (NASA) has an acetyl group added to the N-terminus, which raises stability and resistance to enzymatic degradation. Half-life is correspondingly longer than standard Semax.
Lyophilized Semax should be stored at -20°C for long-term stability (up to 24 months). Protect from heat and direct light.
Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.