Every lot of TESA / IPA Blend is tested by an independent ISO/IEC 17025-accredited lab in the USA. 99%+ purity isn't a target here. It's the requirement.
Don't take our word for it: test any vial at an accredited lab of your choice. If HPLC purity comes back under 99%, we refund your order and pay for the test.
Size
15mg
Purity
99%+ by HPLC · guaranteed
Identity
Confirmed by mass spec
Lab
Freedom Diagnostics · ISO/IEC 17025
About this compound
A two-peptide blend pairing Tesamorelin with Ipamorelin. The two act on separate receptors - GHRH-R and GHS-R - which is the rationale for studying them together in GH-axis research.
Two-peptide research blend: GHRH(1-44) analog (Tesamorelin) + GHS pentapeptide (Ipamorelin)
The numbers that define TESA / IPA Blend and how it is being studied. For laboratory research use only.
2
Receptor Pathways
GHRH-R + GHS-R (ghrelin)
1.3 nM
Ipamorelin EC50
GH release in pituitary cell culture
44 + 5
Amino Acids
Tesamorelin 44 residues, ipamorelin 5
4
Research Areas
GH / IGF-1 Axis Research
GHRH-R + GHS-R Signaling
Body Composition Models
How It Works
How TESA / IPA Blend works
The pathways TESA / IPA Blend acts on - and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
GHRH Receptor Agonism
Tesamorelin Component
Tesamorelin is a synthetic, stabilized analog of human GHRH(1-44). It binds and activates pituitary GHRH receptors, with endogenous growth-hormone secretion measured while the pulsatile release pattern is preserved - unlike exogenous GH administration.
Selective GHRH-receptor agonism at the pituitary
Preserves physiological pulsatile GH secretion
Downstream IGF-1 production measured
Selective GHS-R Agonism
Ipamorelin Component
Ipamorelin is a pentapeptide growth-hormone secretagogue that acts on the ghrelin receptor (GHS-R1a). It is the first highly selective GHS - GH release is measured without accompanying rises in ACTH, cortisol or prolactin.
Acts on the ghrelin receptor (GHS-R1a), a GHRP-like pathway
Highly selective for GH release among secretagogues
Minimal effect on cortisol, prolactin, ACTH in research models
Dual-Receptor GH Axis
Dual-Pathway Design
Pairing a GHRH analog with a ghrelin-receptor secretagogue engages two distinct pituitary pathways. Research into GHRH + GHRP combinations examines whether the two mechanisms act in a complementary fashion on growth-hormone release.
Targets GHRH-R and GHS-R simultaneously
Studied as a complementary, two-pathway research model
Both components act on endogenous GH secretion, not exogenous GH
Uses & Applications
What TESA / IPA Blend is researched for
The main areas TESA / IPA Blend is being studied for - and the study-reported figures behind them.
ENDOCRINOLOGY
GH / IGF-1 Axis Research
Both components are studied as tools for examining endogenous growth-hormone secretion and downstream IGF-1 signaling without exogenous GH.
RECEPTOR PHARMACOLOGY
GHRH-R + GHS-R Signaling
Ipamorelin was characterized as the first selective GHS; pharmacological profiling confirmed it acts via a GHRP-like (ghrelin) receptor.
METABOLIC RESEARCH
Body Composition Models
Tesamorelin is a reference GHRH-analog research model, studied for GH-mediated signalling in visceral adipose tissue.
MUSCULOSKELETAL
Bone Mineral Content
In adult female rats, bone mineral content was measured by DXA following the GH secretagogues ipamorelin and GHRP-6.
Study-reported magnitudes
Representative figures from published research. Bars fill as you scroll.
Tesamorelin: Endogenous GH SecretionMeasured
Ipamorelin: GH-Release SelectivityHigh
Combined GHRH + GHRP PathwaysTwo receptors
Downstream IGF-1 SignalingMeasured
Figures are representative of published research findings and shown for reference.
Molecular Structure
The TESA / IPA Blend molecule
An interactive 3D model rendered from the compound record - rotate and explore its structure.
Tesamorelin CAS 218949-48-5; Ipamorelin CAS 170851-70-4
Physical form
Lyophilized powder
Documented purity
≥99% by HPLC
Compound Information
Full specification
Product Type
Two-peptide research blend
Component 1
Tesamorelin 12 mg - GHRH(1-44) analog
Component 2
Ipamorelin 2 mg - GHS pentapeptide
Tesamorelin Molecular Weight
5135.8 Da
Ipamorelin Molecular Weight
711.86 g/mol
Total Peptide Content
14 mg per vial
Form
Lyophilized powder
Purity
≥99% (HPLC verified)
Testing
Third-party HPLC, Mass Spec, Endotoxin
Storage
-20°C for long-term stability
COA
Included with every order
FAQ
Common questions about TESA / IPA Blend
TESA / IPA is a two-peptide research blend combining Tesamorelin (10 mg) - a stabilized analog of growth-hormone-releasing hormone - with Ipamorelin (5 mg), a selective growth-hormone secretagogue that acts on the ghrelin receptor. The two compounds engage different pituitary pathways involved in growth-hormone release.
Tesamorelin activates the GHRH receptor, mimicking endogenous growth-hormone-releasing hormone. Ipamorelin activates the ghrelin receptor (GHS-R1a), a separate GHRP-like pathway. Both ultimately stimulate endogenous GH secretion, but through distinct receptors - which is the rationale for studying them together.
GHRH analogs and growth-hormone-releasing peptides act on two different receptors in the pituitary. Research into combinations examines whether engaging both pathways produces a complementary effect on growth-hormone release compared with either mechanism alone.
Yes - Ipamorelin was described as the first selective growth-hormone secretagogue. GH release is measured without accompanying rises in ACTH, cortisol, prolactin or other pituitary hormones, even well above the concentration needed for GH release.
An approved pharmaceutical formulation of tesamorelin exists for one clinical indication. Ipamorelin is not approved for human use, and this specific TESA / IPA blend is not an approved product. It is supplied strictly for in vitro laboratory research and is not for human or veterinary use.
Lyophilized blend should be stored at -20°C, protected from light and moisture, to preserve the integrity of both peptides.
Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.
