Every lot of VIP is tested by an independent ISO/IEC 17025-accredited lab in the USA. 99%+ purity isn't a target here. It's the requirement.
Don't take our word for it: test any vial at an accredited lab of your choice. If HPLC purity comes back under 99%, we refund your order and pay for the test.
VIP is a 28-amino acid neuropeptide of the secretin family, studied at the VPAC1 and VPAC2 receptors. Published research covers smooth-muscle relaxation, immunomodulation and neuroprotection endpoints, with cyclic AMP signalling as the principal characterised second messenger. For laboratory research use only.
28-residue neuropeptide studied at VPAC1 and VPAC2 receptors
The numbers that define VIP and how it is being studied. For laboratory research use only.
28
Amino Acids
Secretin peptide family
10 mg
Per Vial
Lyophilized powder
VPAC1/2
Receptor Targets
Class B GPCRs
4
Research Areas
Smooth muscle
Immunomodulation
Neuroprotection
How It Works
How VIP works
The pathways VIP acts on - and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
VPAC1 and VPAC2 Signalling
Receptor
VIP binds the class B G-protein-coupled receptors VPAC1 and VPAC2. Adenylate cyclase activation and cyclic AMP accumulation are the principal characterised readouts.
VPAC1 / VPAC2 engagement
Adenylate cyclase activation
Cyclic AMP accumulation
Smooth Muscle Relaxation
Physiology
Smooth-muscle relaxation endpoints are long characterised for VIP across vascular and gastrointestinal tissue preparations.
Vascular preparations
Gastrointestinal tissue
Relaxation endpoints
Immunomodulatory Endpoints
Immunology
VIP is studied as an endogenous anti-inflammatory mediator, with cytokine-profile shifts measured in immune cell culture.
Cytokine profile shifts
Immune cell culture
Anti-inflammatory mediator
Uses & Applications
What VIP is researched for
The main areas VIP is being studied for - and the study-reported figures behind them.
Physiology
Smooth Muscle Models
Relaxation endpoints are characterised in vascular and gastrointestinal tissue preparations.
Immunology
Immunomodulation
Cytokine-profile endpoints are measured in immune cell culture.
Neuroscience
Neuroprotection Models
VIP appears in neuroprotection literature alongside its receptor-signalling characterisation.
Analytical
Reference Peptide
Used as a characterised VPAC-receptor agonist reference in assay development.
Study-reported magnitudes
Representative figures from published research. Bars fill as you scroll.
VPAC Receptor BindingCharacterised
Cyclic AMP SignallingCharacterised
Smooth Muscle EndpointsMeasured
Immunomodulatory EndpointsMeasured
Figures are representative of published research findings and shown for reference.
Molecular Structure
The VIP molecule
An interactive 3D model rendered from the compound record - rotate and explore its structure.
Molecular model
Sequence length
28 residues
Physical form
Lyophilized powder
Documented purity
≥99% by HPLC
Compound Information
Full specification
Chemical Name
VIP (vasoactive intestinal peptide)
Length
28 amino acids
Family
Secretin peptide family
Content
10 mg per vial
Receptor Targets
VPAC1, VPAC2 (class B GPCRs)
Second Messenger
Cyclic AMP
Form
Lyophilized powder
Purity
≥99% by HPLC
Solubility
Water-soluble
Storage
-20°C, protected from light
Classification
Research use only
FAQ
Common questions about VIP
VPAC1 and VPAC2, both class B G-protein-coupled receptors. Adenylate cyclase activation and cyclic AMP accumulation are the principal characterised readouts.
The molecular weight will be published here from the lot's Certificate of Analysis rather than quoted from a secondary source.
Yes. Both belong to the secretin peptide family and share the VPAC receptors, which is why they are frequently studied together.
Each lot is analysed by reverse-phase HPLC and released at ≥99%, with a Certificate of Analysis.
Store lyophilized at -20°C for long-term stability, protected from light and moisture, and avoid repeated freeze-thaw cycles.
Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.
