T-Cell Research
Used to study thymic-dependent T-lymphocyte maturation and immune cell repopulation in immunosuppressed animal models.
≥99% Purity
Thymosin Alpha-1
Immune Response Studies
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About this compound
Thymosin Alpha-1 is a peptide made of 28 amino acids. It was first isolated from the thymus, an organ where immune cells mature. It occurs naturally as a fragment of a larger protein called prothymosin alpha. Research has measured how immune cells respond to it, including T cell development and the signals dendritic cells send.
28-amino-acid thymic peptide
- Formula
- C129H215N33O55
- Molecular weight
- 3108.29 g/mol
- Form
- Lyophilized Powder
- CAS / ID
- 62304-98-7
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Amino Acid Sequence
Acetylated thymic peptide
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NK-Cell Activity
In-vitro immune models
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Research Areas
T-Cell Research · Viral-Response Models · Tumour-Immunity Models & more
How It Works
How Thymosin Alpha-1 works
The pathways Thymosin Alpha-1 acts on — and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
Thymic Immune Modulation
T-Cell Maturation
T-lymphocyte maturation and differentiation, and the balance of T-cell subsets, are measured in preclinical immunology models following Thymosin Alpha-1.
- T-cell differentiation measured
- Modulates CD4+/CD8+ balance
- Lymphocyte counts measured in immunosuppressed models
Toll-Like Receptor Activation
TLR Signaling
Research indicates Tα1 signals through Toll-like receptors (notably TLR2 and TLR9) on dendritic cells and monocytes, influencing innate-immune activation and cytokine expression.
- Engages TLR2 / TLR9 pathways
- Dendritic-cell maturation
- Modulates cytokine profiles
NK & Th1 Cytokine Modulation
Cytokine / NK
In-vitro and animal studies report raised natural-killer-cell activity and a shift toward a Th1 cytokine profile (IFN-γ, IL-2) - endpoints used in antiviral and antitumour immune-response research.
- NK-cell activity measured
- Th1 cytokine shift (IFN-γ, IL-2)
- Studied in viral and tumour models
Uses & Applications
What Thymosin Alpha-1 is researched for
The main areas Thymosin Alpha-1 is being studied for — and the study-reported figures behind them.
Viral-Response Models
Investigated in hepatitis and other viral models for its influence on innate and adaptive antiviral immunity.
Tumour-Immunity Models
Studied as an immune adjuvant in preclinical tumour models, with NK and cytotoxic T-cell responses as the measured endpoints.
Cytokine Regulation
Examined for modulation of inflammatory cytokine networks and dendritic-cell function in vitro.
Molecular Structure
The Thymosin Alpha-1 molecule
An interactive 3D model rendered from the compound record — rotate and explore its structure.
C129H215N33O55
Compound Information
Full specification
| Strength | 10mg |
| Molecular Formula | C129H215N33O55 |
| Molecular Weight | 3108.29 g/mol |
| Purity | >99% (HPLC) |
| Form | Lyophilized Powder |
| Verified Purity | >99% |
| Quantity | 10mg |
| Appearance | White to off-white powder |
| Stability | 24 months from manufacture date when stored properly |
| Storage | Store at -20°C, protected from light |
FAQ
Common questions about Thymosin Alpha-1
Thymosin Alpha-1 (Tα1) is an acetylated 28-amino-acid peptide originally isolated from thymic tissue (thymosin fraction 5). It is a well-characterized immunomodulator studied for its effects on T-cell maturation, Toll-like-receptor signaling, and innate/adaptive immune balance in cell-culture and animal models.
No. Thymosin Alpha-1 is not approved by the FDA for any use in the United States. A synthetic form (thymalfasin) is approved as an immunomodulator in a number of other countries, but this product is supplied strictly as a reference compound for in-vitro laboratory research.
Store the lyophilized powder at −20°C, protected from light; it is stable for approximately 24 months from manufacture. This is storage guidance for the researcher, not a shipping requirement.
Each lot is ≥99% pure by HPLC with identity confirmed by mass spectrometry and ships with third-party analytical documentation of purity, net peptide content, and endotoxin screening.
Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.